Tryptophan
Interestingly, tryptophan is prescribed in the UK and it has a licence as adjunctive therapy for resistant depression and used only under specialist supervision -
there is risk of eosinophilia-myalgia syndromeand some drug interactions (again ref is the BNF). Snowman (talk) 14:56, 4 December 2008 (UTC)Rating scales
I would agree on creating a separate article with a title similar to rating scales (medicine) ; since it does not exist right now. We would have the info on depression rating scales for the moment and I could easily add some info on the use of cognitive perception deficits questionnaires. We would eliminate one further section which could be easily sumarized into the clinical assessment section. Best regards.
Additionally: is the use of bold and bullets correct in the subtypes section? I don't think bold is needed. Would not italics be more correct?
Finally: I think that the reduction of the history section is a good one: The new article is quite complete. Best regards.--Garrondo (talk) 14:25, 4 December 2008 (UTC)
St John's wort
From my point of view if a treatment is worth a cochrane review it should be included per notability: I would at least leave a line such as: There is inconsistent evidence on the effect of St John's wort extract on major depression. either in the medication or other subsections
Best regards. --Garrondo (talk) 14:52, 4 December 2008 (UTC)
Depression and culture
I would create this subsection in the history section to include the 3 par more historically orientated (historical figures, relation with creativity, and literature as a relief). These 3 paragraphs could be simplified in main article. --Garrondo (talk) 14:57, 4 December 2008 (UTC)
References
Can someone please explain why we are using two different kind of citations styles? I see the typical citet versions, sprinkled with Harvard style. It's messy. If we're concerned about page numbers, then convert all of the references to Harvard style. I personally believe that these articles should never use books as citations, because they are several years out of date upon publication. It's so easy to find secondary sources, oftentimes with full text available, that are far superior to the books. Real science researchers don't use books. Orange Marlin 17:31, 4 December 2008 (UTC)
Expanding 'Other Treatments' Section
I am a therapist and researcher who specializes in non-pharmaceutical treatments for depression. There are several treatments not included in this section that have been shown to treat depression effectively. Some include volunteering, negative ion generators, and multiple nutritional supplements. Please review www.depressiontreatmentworks.org to see if you agree there are several treatments on that site that warrent inclusion. That site is fully referenced. Thank you Postcrypto (talk) 21:31, 4 December 2008 (UTC)
Omega-3 fatty acids
"Evidence for omega-3 fatty acids is too mixed and limited to make a strong conclusion, although the available evidence does not support their use.". Does this say it is not used for MDD? Can it be removed? Snowman (talk) 22:25, 4 December 2008 (UTC)
OK, pages taking a long time to load where I am. Can you see what I meant though? also, I have removed some more from history now. The version of IE on the computer I am at won't let me do Dr PDAs tool properly for some reason. Cheers, Casliber (talk · contribs) 02:25, 5 December 2008 (UTC)
ECT
The ECT section has also deterioriated into more typos & bad sentences. And in the meantime more recent RCTs and surveys have been removed (which happened to show that nearly everyone relapes and even initial remission rates are much lower in practice) in favor of older more positive reviews. And a vital point that some authorities don't recommend maintenance ECT 'cos not evidence-based & may be harmful, was also removed. And then going the other way, critical factual claims added sourced to unreliable Breggin quotes... EverSince (talk) 00:10, 8 November 2008 (UTC)
Strange ref?
Purves, D., Augustine, G. J. et al. "Molecular Mechanisms of Biological Clocks". www.ncbi.nlm.nih.gov. Retrieved on 2008-12-05.
Clicking on this ref, presently #34, takes one to another title with other authors. - Hordaland (talk) 18:01, 5 December 2008 (UTC)
Biological clock human image
1. Does this image describe the circadian rhythm of males only? There is an image of a male in the middle of the clock and testosterone levels are mentioned on the perimeter. Snowman (talk) 20:35, 27 November 2008 (UTC)
2. This diagram appears to be providing a lot of information sourced from a book by Michael Smolensky and Lynne Lamberg (2000). called "The Body Clock Guide to Better Health", as indicated by the image description. Since the image description will not appear on a print out of the page, should this reference appear as an inline ref in the caption? Have there been any changes since 2000? Snowman (talk) 21:04, 27 November 2008 (UTC)
3. I think that this image should be removed. Instead, the text could explain what the commonest sorts of disruption of the circadian rhythm are. Snowman (talk) 13:58, 28 November 2008 (UTC)
- Seems like "biological clock" or "circadian rhythm" is a general concept and not specific to depression. Most of what is in the image, and takes out the most space, is not addressed in this article, eg bowel movement likelihood, fastest reaction time, greatest cardiovascular efficiency, bowel movement suppressed. There is only a one sentence mention in the text.
Major depression may also be caused in part by an overactive hypothalamic-pituitary-adrenal axis (HPA axis) that is similar to the neuro-endocrine response to stress. Investigations reveal increased levels of the hormone cortisol, enlarged pituitary and adrenal glands, and a blunted circadian rhythm.
The image seems irrelevant to the statement in the article. Does this image convey enough information relevant to this article on Major depressive disorder? — Mattisse (Talk) 20:18, 28 November 2008 (UTC)
- But the specific information in the image is not referenced in the article. Are the timings of the bowel movements correct, for example? Is the information in the image scientifically validated? Or is it just someone's compilation? Is the information in the image specific to the issues raised in that section in the article? It is a pretty familiar image, as someone notes, dating back to da Vinci. — Mattisse (Talk) 20:29, 28 November 2008 (UTC)
- The citations you give are are all to popular book reviews. The last one says it is "about a new area of medicine called "chronomedicine" and a new approach to treatment called "chronotherapy". Do you have evidence that chronomedicine and chronotherapy are valid, and researched-based? Quote from one of the book reviews:
"Whether it's arthritis or asthma, diabetes or depression, heart disease or ulcers, breakthroughs in chronomedicine can revolutionize your care. To help you assess your own chronobiological status, the book provides many fill-in diaries that let you track when symptoms worsen or diminish, how medication affects them, how long relief lasts, and whether and when side effects occur."
It sounds more like a self-help book. It gives "tips" on how to get a good night's sleep. The article on chronotherapy is not very convincing. — Mattisse (Talk) 23:54, 28 November 2008 (UTC)
I presume that if page numbers or alternative verification is not provided, then the questioned material can be removed, as is usual on the wiki. Snowman (talk) 23:36, 29 November 2008 (UTC)
- But wait. Cosmic Latte refers above to the difficulty of illustrating this article nicely – yet SandyGeorgia seems to be saying (below) tha
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