The BCR gene is one of the two genes in the bcr-abl complex, which is associated with the Philadelphia chromosome.
Pathology
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
Interactions
BCR gene has been shown to interact with PTPN6, XPB, Feline sarcoma oncogene, GRB10, CD117, Grb2, MLLT4, Abl gene, HCK, SOS1, PIK3CG, CRKL and Paxillin.
See also
- Abl gene
External links
- MeSH BCR+protein,+human
References
- ^ "Entrez Gene: BCR breakpoint cluster region" . http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=613 .
- ^ Liedtke, M; Pandey P, Kumar S, Kharbanda S, Kufe D (Oct. 1998). "Regulation of Bcr-Abl-induced SAP kinase activity and transformation by the SHPTP1 protein tyrosine phosphatase". Oncogene (ENGLAND) 17 (15): 1889-92. doi: 10.1038/sj.onc.1202117 . ISSN 0950-9232. PMID 9788431.
- ^ Takeda, N; Shibuya M, Maru Y (Jan. 1999). "The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (1): 203-7. ISSN 0027-8424. PMID 9874796.
- ^ Lionberger, J M; Smithgall T E (Feb. 2000). "The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl". Cancer Res. (UNITED STATES) 60 (4): 1097-103. ISSN 0008-5472. PMID 10706130.
- ^ a b c Maru, Y; Peters K L, Afar D E, Shibuya M, Witte O N, Smithgall T E (Feb. 1995). "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS". Mol. Cell. Biol. (UNITED STATES) 15 (2): 835-42. ISSN 0270-7306. PMID 7529874.
- ^ a b c d Bai, R Y; Jahn T, Schrem S, Munzert G, Weidner K M, Wang J Y, Duyster J (Aug. 1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL". Oncogene (ENGLAND) 17 (8): 941-8. doi: 10.1038/sj.onc.1202024 . ISSN 0950-9232. PMID 9747873.
- ^ Hallek, M; Danhauser-Riedl S, Herbst R, Warmuth M, Winkler A, Kolb H J, Druker B, Griffin J D, Emmerich B, Ullrich A (Jul. 1996). "Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells". Br. J. Haematol. (ENGLAND) 94 (1): 5-16. ISSN 0007-1048. PMID 8757502.
- ^ Million, R P; Van Etten R A (Jul. 2000). "The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase". Blood (UNITED STATES) 96 (2): 664-70. ISSN 0006-4971. PMID 10887132.
- ^ a b Million, Ryan P; Harakawa Nari, Roumiantsev Sergei, Varticovski Lyuba, Van Etten Richard A (Jun. 2004). "A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase". Mol. Cell. Biol. (United States) 24 (11): 4685-95. doi: 10.1128/MCB.24.11.4685-4695.2004 . ISSN 0270-7306. PMID 15143164.
- ^ a b c Puil, L; Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci P G, Arlinghaus R, Pawson T (Feb. 1994). "Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway". EMBO J. (ENGLAND) 13 (4): 764-73. ISSN 0261-4189. PMID 8112292. ...
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