As usual on talk pages, please start new threads at the bottom of the page.
v • d • e This article is within the scope of WikiProject Pharmacology , a collaborative effort to improve the coverage of Pharmacology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Image permission (2004)
The image of the chemical structure of Clonazepam was taken from http://www.biopsychiatry.com/clonazepam/clonazepam.jpg
I e-mailed the owner of biopsychiatry.com at info@bltc.com and asked permission to use his images and content on Wikipedia.
He replied thus:
David Pearce wrote:
> At 20:03 08/06/2004, you wrote:
>
>> What is your policy on allowing images and text from your HedWeb site to be used on Wikipedia?
>
> Hi Mike
> You're welcome to use anything of interest
> The Wikipedia is a fantastic project!
> very best wishes from sunny Brighton
> Dave
Tobacco concomitantly
Pardon the intrusion. However I am a college student in New York studying chemistry and pharmacology and was wondering if anyone could inform me as to what mechanism of action tobacco's role plays in decreasing the effects of Clonezapam (Klonopin), and Diazepam (Valium). Username: a1970sweet If anyone has any information regarding this matter I would greatly appreciate it and if you could simply post it under my paragraph here. Thank-you.
Problems with References
I tried to clean up some of the inline references such that they show up in the reference heading, but met with very limited success. The reference numbers did start showing up inline, but the full citations aren't appearing.
Some of the references, given only as hyperlinks, seem questionable and should be verified by someone with access to full text Howard C. Berkowitz 21:16, 6 July 2007 (UTC)
Hapten
Would someone clarify? There is an immunological response to Clonazepam?
Dosage equivalents and pharmacology
It should be noted that different benzodiazepines, different people, etc. react differently. I find it hard to believe, based on personal use, that 10 mg diazepam = 0.5 mg Clonazepam, diazepam being "stronger". Is it not true that Clonazepam does not activate as many receptors as Diazepam?
diazepam walks the line where benzo's meet.... something... lol.... and clonazepam has a more spread out less noticable effect than valium. i take clonazepam .5mg 3x a dayClonazepam is stronger than Diazepam (by weight). Both are classic benzos, the difference being Clon. is long-acting and Diazepam short-acting (giving more of a quick "high"). It's similar to the difference between morphine and methadone, and the reason why addicts tend to prefer Xanax (which is as strong as Clon., but short acting). 98.246.184.50 (talk) 16:45, 18 May 2009 (UTC)
Diazepam is actually quite a lot longer acting than clonazepam.-- Literature geek | T@1k? 17:49, 18 May 2009 (UTC)
Safe taking with Sleep Apnea?
Is Clonazepam meant to be taken in the morning after breakfast and/or as a sleep/anxiety aid just before bedtime?
Response: I don't know if it is safe with sleep apnea, but regarding when it is meant to be taken...it depends upon the specific situation of the patient and judgment of the prescribing physician. Anxiety sufferers may take Clonazepam at any time during the day as an "as needed" medication or as a maintenance treatment. For others, it is used as a sleep aid. For example, some anti-depressants are engergizing (Effexor for example) which make it difficult for those taking it to sleep. Low doses of Clonazepam may be prescribed in that situation to be taken in the evening. Tobycat 03:36, 20 Apr 2005 (UTC)
I was diagnosed as a Textbook "REM Sleep disorder", In which I talk, move, and walk during sleep. My Sleep clinic doctor prescribed me 5mg Clonazepam before bedtime, then doubled the dose to 10mg when that didn't do anything for me. Qexter 08:36, 8 Jun 2006 (EST)
5 mg of clonazepam is a huge dose to take all at once; 10 mg - taken as a single dose - is practically an anesthetic. Either you were taking DIazepam (Valium), for which these would be normal doses, or you left out a couple of decimal points. Did you mean 0.5 mg and 1.0 mg, Qexter? If not, and you really were taking these high doses of Klono, you must have been very sleepy the next day. 68.83.140.156 04:56, 24 August 2006 (UTC)Essex9999
I have obstructive sleep apnea (for 16 years now with CPAP) and have been taking 2 mg of Clonazepam about 1 hr before I want to pass out. I awake either six hours later if my bladder is full and go back for my REM sleep (which for me is after six hours of sleep usualy) or usually sleep eight to nine hours. I feel great when I wake up.
What is the dose of Clonazepam conpared to Valium and Xanax?
What is normal dose for medical, and recreational use of clonazepam?
Being a psychiatric nurse and having worked in the field now for a while I suspect the following dosage "equivalents" are wrong. 10 mg of Diazapam is much stronger than 0.5 mg of Clonazapam for ex. and Restoril does not even belong here it is a sleeping medication. Generally Benzodiazapines come in three dosages here in the US and the lowest dose of one correlates with the lowest dosage of another, for example: 0.5 mg Ativan = 0.5 mg Clonazapam = 2 mg Diazapam, etc. Bobyoung53 (talk) 14:59, 24 April 2009 (UTC)
Dosage does not have to increase with use, if medicines are not abused and are taken as prescribed most people do not build up a tolerance. Bobyoung53 (talk) 14:59, 24 April 2009 (UTC)
Hello. You are working on the incorrect assumption that drug doses within a class of drugs are calculated based on equivalency of each other. This may be true for some class of drugs (for example antibiotic classes) but not with all classes. For example if you use opiods as a drug class, the usual therapeutic dose of codeine is not equivalent to the usual therapeutic dose of say diamorphine (heroin), morphine or oxycodone. As you have worked in the field of pscyhiatry, surely you would be aware that clonazepam is what is known as a "high potency" benzodiazepine? If not you can search pubmed for more information on this. High potency benzodiazepines include clonazepam, lorazepam and alprazolam. You should also be aware that generally high doses of benzodiazepines are required for panic disorder. Diazepam doses within usual therpeutic range are not usually high enough for for many people with panic disorder, hence why clonazepam, lorazepam or alprazolam are prefered. Also another reason the newer benzos are stronger than the older therapeutic benzos, is because before a drug can be successfully marketed it has to demonstrate superiority to other benzodiazepines already on the market. Clonazepam, alprazolam and lorazepam are much stronger in the therapeutic doses of diazepam and hence were a success when brought to the market as they were seen as superior in therapeutic effects. I hope that this helps answer your concerns.-- Literature geek | T@1k? 21:11, 24 April 2009 (UTC)
Heart beats and Clonazepam
A daily, small dose of Clonazepam (0.5mg or less) can cause high heart beats? Like 130-150 in a "normal" state, not doing exercise or heavy physical activity.
Response: seems unlikely. I was having some mild panic attacks, with symptoms including a racing heart, and was prescribed low dose Clonazepam for as-needed treatment.
unless your having a very rare side effect and getting panic attacks from an axiety med... than if say your either mixing it with something... you smoke ciggerettes...drink alot of coffee... or your alergic(anything that stimulates the CNS like nicotine or caffeine metabolizes the klonopin alot faster than normal which can cause panic attacks... but the mostly likly cause of tachycardia after taking a benzo is an allergy or an unlucky adverse reaction)
Indication vs. Approval
Regarding Davidruben's revert to the indications section (http://en.wikipedia.org/w/index.php?title=Clonazepam&diff=prev&oldid=74429734): Look at the sentence on Tourette Syndrome. It's clearly confusing FDA approval with the more general concept of a commonly-accepted use. And what's the point of even mentioning that something is an off-label use (which is, after all, a US-specific regulatory issue) in a general article on the substance? I can see it in the case of Vioxx, but not here. KonradG 00:53, 8 September 2006 (UTC)
Clonazepam Hangover
I am a long-term user of Clonazepam for generalized anxiety disorder since I was 17 and I and others who have taken my medication have noticed a distinct "Clonazepam Hangover" effect. When you take it before you go to bed, you wake up feeling many similar symptoms of an alcohol